drug delivery TO and within THE BRAIN

Due to its highly selective properties, the blood-brain barrier (BBB) represents a substantial obstacle for drug delivery to the central nervous system (CNS). We have multiple projects focused on improving drug delivery to and within the brain. One project focuses on circumventing the BBB after systemic injection, while another project focuses on how biological drugs move around the brain after direct injection into cerebrospinal fluid, which bypasses the BBB. Both projects examine structure/function relationships using orthogonal outcome measure assessments and leverage a variety of in vivo models and analytical techniques.

Relevant contacts

Alex Sorets, Adam Abdulrahman, Sarah Lyons, Alex Ligocki

Relevant publications

Caveolae-mediated transport at the injured blood-brain barrier as an underexplored pathway for central nervous system drug delivery

Albumin-binding aptamer chimeras for improved siRNA bioavailability

Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system