neurovascular and neurodegenerative disease mechanisms

Neurodegeneration pipeline 3.jpg

We have built robust experimental pipelines that allow us to interrogate disease phenotypes in our in vitro models, with complementary and follow-up analyses in animal models and human tissue samples. The in vivo and tissue data also feed back into in vitro model development to better recapitulate the disease being studied. Currently, our interests are centered around Alzheimer’s disease, cerebral amyloid angiopathy, and general tauopathies. We are also very interested in any condition that may yield blood-brain barrier dysfunction as a cause or consequence of disease.

Relevant contacts

Hyosung Kim, Lauren Drake, Andrew Kjar, Rebecca Embalabala, Elaina Ziehm, Alex Ligocki

Relevant publications

Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin